Multiple Target Laser Designator ( MTLD ) Quarterly Status Report # 6 Contract No . N 00014 - 05 - C - 0423

Ocular Laser Injuries

Type Device Wavelength (nm) Band Helium-Neon Tank, gunnery trainer 642.8 Visible (red) Ruby Rangefinder 694.3 Visible (red) Gallium-Arsenide MILES 905.0 Near-infrared Nd:YAG Rangefinder, target designator 1,064.0 Near-infrared Carbon Dioxide Rangefinder 10,600.0 Far-infrared MILES: multiple integrated laser engagement system Nd:YAG: neodymium:yttrium-aluminum-garnet Adapted from Headquarters, D...

MTLD, a Database of Multiple Target Ligands, the Updated Version.

Polypharmacology plays an important role in drug discovery and polypharmacology drug strategies provide a novel path in drug design. However, to develop a polypharmacology drug with the desired profile remains a challenge. Previously, we developed a free web-accessible database called Multiple Target Ligand Database (MTLD, www.mtdcadd.com). Herein, the MTLD database has been updated, containing...

Final Report on the Contract - N 00014 - 97 - 1 - 0917 Title Distributed Sensor Fusion Based on Statistical Inference

Creation of a free, Internet-accessible database: the Multiple Target Ligand Database

BACKGROUND Polypharmacology plays an important part in drug discovery, and remains a major challenge in drug development. Identification of the underlying polypharmacology of a drug, as well as development of polypharmacological drugs, have become important issues in the pharmaceutical industry and academia. DESCRIPTION Herein, through data mining of the Protein Data Bank (PDB), a free, Inter...

Specific inhibition of procollagen C-endopeptidase activity by synthetic peptide with conservative sequence found in chordin.

Procollagen C-endopeptidase (BMP-1) and N-endopeptidase (ADAMTS-2) are key enzymes for correct and efficient conversion of fibrillar procollagens to their self assembling monomers. Thus, they have an essential role in building and controlling the quality of extracellular matrices (ECMs). Here, we tested inhibition of activity of the largest variant of BMP-1, a recombinant mammalian tolloid (mTl...